How to beat prion brutal mode in plague inc

Using my strategy, you save up tons of points. The key is to have a massive stockpile of points already in place and then evolve the symptoms you need to kill the population quickly when they are all infected.

If you do feel as though more points are required, you can let the game run by itself for awhile after you have infected everyone. Mutation risk should be extremely low and you will continue to get the stray point every once in awhile.

Basically the last leg of the strategy is to kill everyone faster than they can cure your disease. If you are worried it might not work, it might be useful to create a save at the point where everyone is infected.

Hmm. I only play on the PC version, where it works very well. As for mobile, I am unsure.

The underlying strategy is to not try infecting countries too fast. Minimize the number of points spent and avoid getting any symptoms until every person in the world is infected. It is basically just one big sneak attack, where you do not want them to know you are there until it is too late.

Keeping Severity down really low and avoiding lethality seems to work well at staying uncovered in Brutal difficulty and lower on PC. Megabrutal will always discover you at a point, which makes things really difficult.

I have done tutorials on youtube a few weeks ago :

And first, don’t believe those who tell you to play with no symptoms at all, like only noobs do. It’s what makes you miss DNA at the end.
When you “even tried to evolve Necrosis tree down when Greenland was half infected”, you were extremely late to take necrosis “even” in this game.

You can’t win challenging games if you don’t play them. The game is to take calculated risks. I have done all the runs of my tutorial channel in 1 to 3 tries. It’s not much, but it can’t be 100% sure. The turorials promising a 100% in brutal lie.

So I shouldn’t go subtle? Even with the coughing symptom they’ll find me and start working on a cure in the blink of an eye.

And first, don’t believe those who tell you to play with no symptoms at all, like only noobs do. It’s what makes you miss DNA at the end.
When you “even tried to evolve Necrosis tree down when Greenland was half infected”, you were extremely late to take necrosis “even” in this game.

You can’t win challenging games if you don’t play them. The game is to take calculated risks. I have done all the runs of my tutorial channel in 1 to 3 tries. It’s not much, but it can’t be 100% sure. The turorials promising a 100% in brutal lie.

Hey! No need for bashing my play style.

I was just trying to help with completing the Prion on Brutal. The forum is open to anyone and I am glad that you decided to add in your opinion.

However, broadly accusing people of being “noobs” is unnecessary. I am just trying to help and that kind of language is what prevents people from giving input on subject matters which they might contribute something helpful towards.

I respect your experience on the game Olivier and appreciate your input. Derogatory language is unnecessary for conveying your knowledge.

Alright, here we go.

Choose these starting Genes
Genetic Mimic (Just because)
Aquacyte (Just because)
Translesion (Devolving always gives points back instead of gradually starting to cost points)
Extremeophile (Just because)
Metabolic Hijack (No manually popping bubbles. Because it gets annoying when playing the long games)

Strategy
Start in India (Right below China)
Devolve all symptoms until you infect every single person. No taking chances, EVERY person.
Give your disease Air 1, Water 1, Drug Resistance 1 and Cold Resistance 1 + 2. Nothing else. Patience is key.

Now begins the waiting game. Wait until every single person is infected. Once they are, evolve the symptoms Insomnia, Paranoia, Coma, and Total Organ Failure. Also any I forgot to mention in that progression, plus all other super dangerous symptoms you want to evolve.

Then wait. If you want, improve cure resistance through the Abilities tree. You should win easily though.

This no longer works. I used 150 ♥♥♥♥♥♥♥ points to develop every single massively lethal sympton in the game after infecting everyone on earth and they developed the cure before I had killed a billion people. The devs must have changed something dramatic because prion mega brutal is almost literally impossible to beat ATM.

Unfortunately, my strategy does not work on Mega Brutal. I believe Mega Brutal allows your disease to be detected automatically once enough of the Starting Country population is infected. The method should work on Brutal, but not on Mega Brutal.

I apologize for not being more helpful in this regard, but I wish you good luck in your future attempts.

This no longer works. I used 150 ♥♥♥♥♥♥♥ points to develop every single massively lethal sympton in the game after infecting everyone on earth and they developed the cure before I had killed a billion people. The devs must have changed something dramatic because prion mega brutal is almost literally impossible to beat ATM.

Unfortunately, my strategy does not work on Mega Brutal. I believe Mega Brutal allows your disease to be detected automatically once enough of the Starting Country population is infected. The method should work on Brutal, but not on Mega Brutal.

I apologize for not being more helpful in this regard, but I wish you good luck in your future attempts.

Unfortunately, my strategy does not work on Mega Brutal. I believe Mega Brutal allows your disease to be detected automatically once enough of the Starting Country population is infected. The method should work on Brutal, but not on Mega Brutal.

I apologize for not being more helpful in this regard, but I wish you good luck in your future attempts.

It also no longer seems to work on brutal, just tried.

Prion on Brutal in Plague Inc. is probably the longest plague type I have played so far.

It took me a whopping 2064 days to beat this one, primarily because of Canada. I couldn’t swing a way to afford Drug Resistance 1 at the end without screwing myself.

I might have to work on this one later, but for now this one just requires a ton of patience.

Quick tip: Any time I mention devolving symptoms immediately, that means don’t close the notification first, go immediately to the symptoms page and devolve it, otherwise that brief second is enough time to alert the world that your plague exists, which makes beating the plague nearly impossible.

Also, purchasing anything outside of what’s listed in this guide may risk you not having enough points at the end, so don’t say I didn’t warn you!

Gene Setup for Prion on Brutal

DNA Gene: Metabolic Hack – Pops orange and red DNA bubbles automatically. This is a very long plague, so this ability allows you to set your phone down for a while and let the points come on their own.
Travel Gene: Teracyte – Increases the chance of your plague spreading by land.
Evolution Gene: Sympto-Stasis – Symptom costs don’t increase, but easier to cure, this one is important for this strategy.
Mutation Gene: Creationist – Decreases the chance of mutating symptoms, absolutely crucial for this really long plague type.
Environment Gene: Extremophile – Minor bonus in all environments.

Starting your Prion Plague

The basic strategy here, like most of the other plague types, is to remain undetected until everyone on the planet is infected, bank up some points, and then unleash hell upon the population.

Phase 1

  • Start in India – Hot country with an airport and seaport
  • Transmissions: Air 1, Water 1
  • Symptoms: None, devolve all mutations immediately
  • Abilities: Cold Resistance 1,

Phase 2

  • Transmissions: Livestock 1
  • Symptoms: None, devolve all mutations immediately
  • Abilities: Cold Resistance 2

Phase 3

  • Transmissions: None
  • Symptoms: None, devolve all mutations immediately
  • Abilities: Neural Atrophy 1, 2, and 3

Phase 4

  • Ride this out racking up points and devolving anything that pops up immediately
  • Canada and Greenland will likely be the last to spread, and very slowly at that so you’ll be waiting on them for a while
  • Once you have 63 points banked up and the entire world is infected, it’s time to finally destroy them!

Phase 5

  • Time to unleash hell! Once everyone in the world is infected and you have at least 63 points, purchase Cysts, Hyper Sensitivity, Paralysis, Coma, and Total Organ Failure to start killing people off, and throw some extra points at fun stuff like Internal Hemorrhaging, Hemorrhagic Shock, and Necrosis if you have extra
  • The cure will start to rise quickly, but don’t panic.. you’ll be racking up points quickly as well as the world dies off

Using my strategy, you save up tons of points. The key is to have a massive stockpile of points already in place and then evolve the symptoms you need to kill the population quickly when they are all infected.

If you do feel as though more points are required, you can let the game run by itself for awhile after you have infected everyone. Mutation risk should be extremely low and you will continue to get the stray point every once in awhile.

Basically the last leg of the strategy is to kill everyone faster than they can cure your disease. If you are worried it might not work, it might be useful to create a save at the point where everyone is infected.

Hmm. I only play on the PC version, where it works very well. As for mobile, I am unsure.

The underlying strategy is to not try infecting countries too fast. Minimize the number of points spent and avoid getting any symptoms until every person in the world is infected. It is basically just one big sneak attack, where you do not want them to know you are there until it is too late.

Keeping Severity down really low and avoiding lethality seems to work well at staying uncovered in Brutal difficulty and lower on PC. Megabrutal will always discover you at a point, which makes things really difficult.

I have done tutorials on youtube a few weeks ago :

And first, don’t believe those who tell you to play with no symptoms at all, like only noobs do. It’s what makes you miss DNA at the end.
When you “even tried to evolve Necrosis tree down when Greenland was half infected”, you were extremely late to take necrosis “even” in this game.

You can’t win challenging games if you don’t play them. The game is to take calculated risks. I have done all the runs of my tutorial channel in 1 to 3 tries. It’s not much, but it can’t be 100% sure. The turorials promising a 100% in brutal lie.

So I shouldn’t go subtle? Even with the coughing symptom they’ll find me and start working on a cure in the blink of an eye.

And first, don’t believe those who tell you to play with no symptoms at all, like only noobs do. It’s what makes you miss DNA at the end.
When you “even tried to evolve Necrosis tree down when Greenland was half infected”, you were extremely late to take necrosis “even” in this game.

You can’t win challenging games if you don’t play them. The game is to take calculated risks. I have done all the runs of my tutorial channel in 1 to 3 tries. It’s not much, but it can’t be 100% sure. The turorials promising a 100% in brutal lie.

Hey! No need for bashing my play style.

I was just trying to help with completing the Prion on Brutal. The forum is open to anyone and I am glad that you decided to add in your opinion.

However, broadly accusing people of being “noobs” is unnecessary. I am just trying to help and that kind of language is what prevents people from giving input on subject matters which they might contribute something helpful towards.

I respect your experience on the game Olivier and appreciate your input. Derogatory language is unnecessary for conveying your knowledge.

Alright, here we go.

Choose these starting Genes
Genetic Mimic (Just because)
Aquacyte (Just because)
Translesion (Devolving always gives points back instead of gradually starting to cost points)
Extremeophile (Just because)
Metabolic Hijack (No manually popping bubbles. Because it gets annoying when playing the long games)

Strategy
Start in India (Right below China)
Devolve all symptoms until you infect every single person. No taking chances, EVERY person.
Give your disease Air 1, Water 1, Drug Resistance 1 and Cold Resistance 1 + 2. Nothing else. Patience is key.

Now begins the waiting game. Wait until every single person is infected. Once they are, evolve the symptoms Insomnia, Paranoia, Coma, and Total Organ Failure. Also any I forgot to mention in that progression, plus all other super dangerous symptoms you want to evolve.

Then wait. If you want, improve cure resistance through the Abilities tree. You should win easily though.

This no longer works. I used 150 ♥♥♥♥♥♥♥ points to develop every single massively lethal sympton in the game after infecting everyone on earth and they developed the cure before I had killed a billion people. The devs must have changed something dramatic because prion mega brutal is almost literally impossible to beat ATM.

Unfortunately, my strategy does not work on Mega Brutal. I believe Mega Brutal allows your disease to be detected automatically once enough of the Starting Country population is infected. The method should work on Brutal, but not on Mega Brutal.

I apologize for not being more helpful in this regard, but I wish you good luck in your future attempts.

This no longer works. I used 150 ♥♥♥♥♥♥♥ points to develop every single massively lethal sympton in the game after infecting everyone on earth and they developed the cure before I had killed a billion people. The devs must have changed something dramatic because prion mega brutal is almost literally impossible to beat ATM.

Unfortunately, my strategy does not work on Mega Brutal. I believe Mega Brutal allows your disease to be detected automatically once enough of the Starting Country population is infected. The method should work on Brutal, but not on Mega Brutal.

I apologize for not being more helpful in this regard, but I wish you good luck in your future attempts.

Unfortunately, my strategy does not work on Mega Brutal. I believe Mega Brutal allows your disease to be detected automatically once enough of the Starting Country population is infected. The method should work on Brutal, but not on Mega Brutal.

I apologize for not being more helpful in this regard, but I wish you good luck in your future attempts.

It also no longer seems to work on brutal, just tried.

Beating Prion on Normal in Plague Inc. is a little tough at first since it’s a fairly slow plague type. You’ll play it similar to how you played Fungus and Parasite, but the special ability isn’t nearly as good.

This is another “slow and go” plague type that takes a lot of time to spread, so be patient and don’t get too hasty.

Quick tip: Any time I mention devolving symptoms immediately, that means don’t close the notification first, go immediately to the symptoms page and devolve it, otherwise that brief second is enough time to alert the world that your plague exists, which makes your job a lot more difficult.

Gene Setup for Prion on Normal

I did this one with no genes selected, so feel free to add some if you’re having troubles, but it shouldn’t be tough at all if you follow this guide properly.

Starting your Prion Plague

Phase 1

  • Start in India – Hot country with an airport and seaport
  • Transmissions: Air 1, Water 1
  • Symptoms: Cysts
  • Abilities: Cold Resistance 1

Phase 2

  • Transmissions: Livestock 1
  • Symptoms: Devolve all mutations immediately
  • Abilities: Cold Resistance 2

Phase 3

  • Transmissions: None
  • Symptoms: Devolve all mutations immediately
  • Abilities: Neural Atrophy 1, 2, and 3

Phase 4

  • Ride this out racking up points and devolving anything that pops up immediately
  • Countries like Canada and Greenland will likely be the last to infect and spread, so be patient and let your plague do its thing
  • Once you have 70+ points banked up (you should have a lot more than that if you followed this closely) then it’s time to have some fun

Phase 5

  • Time to unleash hell! Once everyone in the world is infected and you have about 70+ points, purchase Hyper Sensitivity, Paralysis, Coma, and Total Organ Failure to start killing people off, and throw some extra points at fun stuff like Internal Hemorrhaging, Hemorrhagic Shock, and Necrosis
  • The cure will start to rise quickly, but don’t panic.. you’ll be racking up points quickly the population dies off
  • Purchase Genetic Hardening and Genetic Reshuffle if you’d like to reduce the cure amount and increase your final score a bit

Apparently a lot of people thought that Brutal was a cake walk in the original versions of Plague Inc.

Honestly, it wasn’t super difficult once you got used to the mechanics of the game and the plague type, but the devs have answered with MEGA Brutal mode, which at first seems pretty crazy.

Mega Brutal adds several different mechanics, from random blood tests that detect your plague without any symptoms, to huge increases in ability costs the more people that are infected with your plague.

After many futile attempts, I’ve cracked the code on Mega Brutal Bacteria.

Here is the Gene setup:

Gene Setup for Mega Brutal Bacteria

DNA Gene – Metabolic Jump

Travel Gene – Aquacyte

Evolution Gene – Symptostasis

Mutation Gene – Genetic Mimic

Environment Gene – Extremophile

Mega Brutal Bacteria Strategy

The best way to run against this mechanic is very aggressively with symptoms, but try to keep your severity low.

Starting country: China – I have been running with India a lot lately, but every time I tried India on this one, the minute Greenland got infected it would stop spreading immediately and I would end up losing.

Buy these symptoms first: Nausea, Coughing, Rash, Anaemia, Cysts

Next buy these transmissions: Water 1, Insect 1

Then buy these abilities: Bacterial Resilience 1, Drug Resistance 1

At this point your plague should be spreading throughout China pretty quickly since you have a decent amount of infectivity. It’s time to turn it up a notch though. Once your plague starts spreading, you’ll be gaining a lot of bonus points to spend from Metabolic Jump and having a lot of symptoms.

Buy these transmissions next: Water 2, Insect 2

Some more symptoms: Sneezing, Pneumonia, Vomitting, Sweating, Haemophilia, Abscesses, Hyper Sensitivity

Next buy these abilities: Bacterial Resilience 2 and 3, Genetic Hardening 1 and 2, Drug Resistance 2

Your plague will be spreading like crazy at this point from your huge infectivity, giving you points faster than you can spend (nearly). Remember however that the more of the population that is infected, the more all of your abilities are going to cost, which is a very frustrating mechanic at the end of the game.

At this point, keep an eye on symptoms that mutate, and devolve any that are extremely lethal and / or severe, because you don’t want countries shutting down their borders before they are infected.

Keep evolving symptoms like Diarrhea, Pulmonary Fibrosis, Skin Lesions. If the cure starts to build too quickly, throw in Paralysis and Coma. You can also purchase some Genetic Reshuffles as needed, but they might be really expensive by now.

Once all countries are infected and you get a decent population that’s infected, throw in the Necrosis symptom to speed things up a bit.

Once everyone is infected, it’s time to let out the Demons! Throw the book at them with whatever points you have left. Total Organ Failure, Internal Haemorrhaging, Dysentery, etc. The population will die extremely fast and..

Congrats, you win!

How to beat prion brutal mode in plague inc

If you’re having trouble or have some suggestions, leave comments below and let me know.

Plague Inc: Evolved

The unusual thing about Prion is that its “Maximum Lethality Increase” value is very low. Even when the Lethality bar is nearly filled, the *actual* lethality level is gradually, invisibly increasing over time – but the Severity level rises almost immediately (that’s what the Severity lowering abilities are for).

This means that you have to plan ahead, you can’t just evolve lethal symptoms and expect everyone to drop dead, you have to start evolving lethality early and then keep pushing Infectivity so that the world is infected by the time the deaths start actually happening. Otherwise everyone will notice that your global plague is starting to become deadly (no matter how low severity is people will notice deaths), freak out and cure it almost immediately before your *real* lethality level is high enough to make a dent.

The game should probably make this more clear. It does tell you that Prion is “slow” but it doesn’t tell you what that actually means. There should really be two indicator bars for each trait, or a smaller, darker-colored indicator inside the main one (one showing your evolved level and one showing your *actual* level). But there isn’t, so you have to eyeball it.

The problem is not the game but the way you play it.

Winning with prion in brutal or mega-brutal demands some skills, because the margin is quite tight between starting to kill soon enough (because of the slow lethality) and getting every islands before they are closed. You have to make a good run and calculate your risks wisely.

For example, if you have started to play like noobs (and the tutorials they pretend to write) always tell you, by playing with no symptoms at all before you have infected entirely the world population, and take all the symptoms at the same time. then you have simply not started at all to learn how to play. That is why you can’t do anything on a challenge that demands game skills. If you are in this case, you have to restart to learn how to play from the begining.

Mobile and PC versions are not very different on this. You can look at the video tutorials I have done for the PC version and use them on mobile.

Apparently a lot of people thought that Brutal was a cake walk in the original versions of Plague Inc.

Honestly, it wasn’t super difficult once you got used to the mechanics of the game and the plague type, but the devs have answered with MEGA Brutal mode, which at first seems pretty crazy.

Mega Brutal adds several different mechanics, from random blood tests that detect your plague without any symptoms, to huge increases in ability costs the more people that are infected with your plague.

After many futile attempts, I’ve cracked the code on Mega Brutal Bacteria.

Here is the Gene setup:

Gene Setup for Mega Brutal Bacteria

DNA Gene – Metabolic Jump

Travel Gene – Aquacyte

Evolution Gene – Symptostasis

Mutation Gene – Genetic Mimic

Environment Gene – Extremophile

Mega Brutal Bacteria Strategy

The best way to run against this mechanic is very aggressively with symptoms, but try to keep your severity low.

Starting country: China – I have been running with India a lot lately, but every time I tried India on this one, the minute Greenland got infected it would stop spreading immediately and I would end up losing.

Buy these symptoms first: Nausea, Coughing, Rash, Anaemia, Cysts

Next buy these transmissions: Water 1, Insect 1

Then buy these abilities: Bacterial Resilience 1, Drug Resistance 1

At this point your plague should be spreading throughout China pretty quickly since you have a decent amount of infectivity. It’s time to turn it up a notch though. Once your plague starts spreading, you’ll be gaining a lot of bonus points to spend from Metabolic Jump and having a lot of symptoms.

Buy these transmissions next: Water 2, Insect 2

Some more symptoms: Sneezing, Pneumonia, Vomitting, Sweating, Haemophilia, Abscesses, Hyper Sensitivity

Next buy these abilities: Bacterial Resilience 2 and 3, Genetic Hardening 1 and 2, Drug Resistance 2

Your plague will be spreading like crazy at this point from your huge infectivity, giving you points faster than you can spend (nearly). Remember however that the more of the population that is infected, the more all of your abilities are going to cost, which is a very frustrating mechanic at the end of the game.

At this point, keep an eye on symptoms that mutate, and devolve any that are extremely lethal and / or severe, because you don’t want countries shutting down their borders before they are infected.

Keep evolving symptoms like Diarrhea, Pulmonary Fibrosis, Skin Lesions. If the cure starts to build too quickly, throw in Paralysis and Coma. You can also purchase some Genetic Reshuffles as needed, but they might be really expensive by now.

Once all countries are infected and you get a decent population that’s infected, throw in the Necrosis symptom to speed things up a bit.

Once everyone is infected, it’s time to let out the Demons! Throw the book at them with whatever points you have left. Total Organ Failure, Internal Haemorrhaging, Dysentery, etc. The population will die extremely fast and..

Congrats, you win!

How to beat prion brutal mode in plague inc

If you’re having trouble or have some suggestions, leave comments below and let me know.

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